Potential Role of Vitamin D in the Elderly to Resist COVID-19 and to Slow Progression of Parkinson's Disease.
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Auteurs : Casey A. Hribar [États-Unis] ; Peter H. Cobbold [Royaume-Uni] ; Frank C. Church [États-Unis]Source :
- Brain sciences [ 2076-3425 ] ; 2020.
Abstract
While we are still learning more about COVID-19, caused by the novel SARS-CoV-2 virus, finding alternative and already available methods to reduce the risk and severity of the disease is paramount. One such option is vitamin D, in the form of vitamin D3 (cholecalciferol) supplementation, due to its potential antiviral properties. It has become apparent that older individuals have a greater risk of developing severe COVID-19, and compared to younger adults, the elderly have lower levels of vitamin D due to a variety of biological and behavioral factors. Older adults are also more likely to be diagnosed with Parkinson's disease (PD), with advanced age being the single greatest risk factor. In addition to its immune-system-modulating effects, it has been suggested that vitamin D supplementation plays a role in slowing PD progression and improving PD-related quality of life. We completed a review of the literature to determine the relationship between vitamin D, PD, and COVID-19. We concluded that the daily supplementation of 2000-5000 IU/day of vitamin D3 in older adults with PD has the potential to slow the progression of PD while also potentially offering additional protection against COVID-19.
DOI: 10.3390/brainsci10050284
PubMed: 32397275
PubMed Central: PMC7287983
Affiliations:
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Cobbold</name><affiliation wicri:level="1"><nlm:affiliation>Emeritus Professor, Department of Human Anatomy and Cell Biology, University of Liverpool, Liverpool L69 3EG, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Emeritus Professor, Department of Human Anatomy and Cell Biology, University of Liverpool, Liverpool L69 3EG</wicri:regionArea><wicri:noRegion>Liverpool L69 3EG</wicri:noRegion></affiliation></author><author><name sortKey="Church, Frank C" sort="Church, Frank C" uniqKey="Church F" first="Frank C" last="Church">Frank C. Church</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27759, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27759</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32397275</idno><idno type="pmid">32397275</idno><idno type="doi">10.3390/brainsci10050284</idno><idno type="pmc">PMC7287983</idno><idno type="wicri:Area/Main/Corpus">000222</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000222</idno><idno type="wicri:Area/Main/Curation">000222</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000222</idno><idno type="wicri:Area/Main/Exploration">000222</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Potential Role of Vitamin D in the Elderly to Resist COVID-19 and to Slow Progression of Parkinson's Disease.</title><author><name sortKey="Hribar, Casey A" sort="Hribar, Casey A" uniqKey="Hribar C" first="Casey A" last="Hribar">Casey A. Hribar</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27759, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27759</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Cobbold, Peter H" sort="Cobbold, Peter H" uniqKey="Cobbold P" first="Peter H" last="Cobbold">Peter H. Cobbold</name><affiliation wicri:level="1"><nlm:affiliation>Emeritus Professor, Department of Human Anatomy and Cell Biology, University of Liverpool, Liverpool L69 3EG, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Emeritus Professor, Department of Human Anatomy and Cell Biology, University of Liverpool, Liverpool L69 3EG</wicri:regionArea><wicri:noRegion>Liverpool L69 3EG</wicri:noRegion></affiliation></author><author><name sortKey="Church, Frank C" sort="Church, Frank C" uniqKey="Church F" first="Frank C" last="Church">Frank C. Church</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27759, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27759</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></analytic><series><title level="j">Brain sciences</title><idno type="ISSN">2076-3425</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">While we are still learning more about COVID-19, caused by the novel SARS-CoV-2 virus, finding alternative and already available methods to reduce the risk and severity of the disease is paramount. One such option is vitamin D, in the form of vitamin D<sub>3</sub> (cholecalciferol) supplementation, due to its potential antiviral properties. It has become apparent that older individuals have a greater risk of developing severe COVID-19, and compared to younger adults, the elderly have lower levels of vitamin D due to a variety of biological and behavioral factors. Older adults are also more likely to be diagnosed with Parkinson's disease (PD), with advanced age being the single greatest risk factor. In addition to its immune-system-modulating effects, it has been suggested that vitamin D supplementation plays a role in slowing PD progression and improving PD-related quality of life. We completed a review of the literature to determine the relationship between vitamin D, PD, and COVID-19. We concluded that the daily supplementation of 2000-5000 IU/day of vitamin D<sub>3</sub> in older adults with PD has the potential to slow the progression of PD while also potentially offering additional protection against COVID-19.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32397275</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">2076-3425</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><Issue>5</Issue><PubDate><Year>2020</Year><Month>May</Month><Day>08</Day></PubDate></JournalIssue><Title>Brain sciences</Title><ISOAbbreviation>Brain Sci</ISOAbbreviation></Journal><ArticleTitle>Potential Role of Vitamin D in the Elderly to Resist COVID-19 and to Slow Progression of Parkinson's Disease.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E284</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/brainsci10050284</ELocationID><Abstract><AbstractText>While we are still learning more about COVID-19, caused by the novel SARS-CoV-2 virus, finding alternative and already available methods to reduce the risk and severity of the disease is paramount. One such option is vitamin D, in the form of vitamin D<sub>3</sub> (cholecalciferol) supplementation, due to its potential antiviral properties. It has become apparent that older individuals have a greater risk of developing severe COVID-19, and compared to younger adults, the elderly have lower levels of vitamin D due to a variety of biological and behavioral factors. Older adults are also more likely to be diagnosed with Parkinson's disease (PD), with advanced age being the single greatest risk factor. In addition to its immune-system-modulating effects, it has been suggested that vitamin D supplementation plays a role in slowing PD progression and improving PD-related quality of life. We completed a review of the literature to determine the relationship between vitamin D, PD, and COVID-19. We concluded that the daily supplementation of 2000-5000 IU/day of vitamin D<sub>3</sub> in older adults with PD has the potential to slow the progression of PD while also potentially offering additional protection against COVID-19.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hribar</LastName><ForeName>Casey A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27759, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cobbold</LastName><ForeName>Peter H</ForeName><Initials>PH</Initials><AffiliationInfo><Affiliation>Emeritus Professor, Department of Human Anatomy and Cell Biology, University of Liverpool, Liverpool L69 3EG, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Church</LastName><ForeName>Frank C</ForeName><Initials>FC</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27759, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Brain Sci</MedlineTA><NlmUniqueID>101598646</NlmUniqueID><ISSNLinking>2076-3425</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Parkinson’s disease</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">antiviral</Keyword><Keyword 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Hribar</name></region><name sortKey="Church, Frank C" sort="Church, Frank C" uniqKey="Church F" first="Frank C" last="Church">Frank C. Church</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Cobbold, Peter H" sort="Cobbold, Peter H" uniqKey="Cobbold P" first="Peter H" last="Cobbold">Peter H. Cobbold</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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